10.1007/s00726-011-1206-6 Summary Keywords Pichia pastoris, peptide-crossing-blood-brain-barrier, delta-sleepinducing peptide, neurotransmitter balance, mouse model, PCPA-induced insomnia Citation Mu X, Qu L, Yin L, Wang L, Liu X and Liu D (2024) Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models
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However, despite low plasma concentrations, pharmacokinetic studies show that berberine has a high tissue distribution rate, accumulating effectively in the liver, kidneys, muscle, and heart where it exerts its metabolic effects
MUL1, Mitochondrial ubiquitin ligase 1
Peptides are strings of amino acids smaller than a protein that often act as signaling molecules in our bodies and carry out many critical functions
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