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Similarly, the impact of genetic variation in pharmacogenes ( CYP-450 ) and other genes ( GATM , CoQ 2 , etc.) have been largely inconclusive

J Steroid Biochem Mol Biol (2018) 182:2736

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doi: 10.1016/j.neuint.2009.07.011

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Intravenous administration is more likely to increase plasma carnitine concentration, yet homeostatic mechanisms tightly control blood concentration through metabolism and renal excretion: Up to 90% of 2 g of L-carnitine administered intravenously is excreted into the urine within 12 to 24 hours