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Based upon these results, disruption of the BBB and ischemia-induced inflammation could be ameliorated by Ex-4 in an astrocyte-dependent way

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Labarrere and Kassab, 2021

PAB rats at both time points showed significant pathology compared to Sham, including RV dilation and dysfunction, which were recorded as increased right ventricular end-diastolic area (RVEDA), and decreased right ventricular fractional area change (RVFAC) and tricuspid annular plane systolic excursion (TAPSE)