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2): (1) needle puncture models, (2) mechanical models that apply abnormal mechanical stress to the IVD, and (3) spontaneous IDD models

Choi JH, Ro JY

PubMed Sakanoue M, Sanada J, Kanekura T

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Restored PI3K/Akt signaling and increased GLUT1/GLUT3 expression ( ameliorated memory deficits, reduced amyloid burden, improved gut microbiota composition, reduced pro-inflammatory markers (IL-6, IL-1), and enhanced antioxidative enzymes (SOD, IL-4) (Gu et al., 2021)

Potential side effects range from minor skin irritations to more severe complications, such as kidney problems and potentially life-threatening allergic reactions