These two genes were duplicated during the second whole-genome duplication event (2R) to create four new somatostatin genes: SS1, SS2, SS3 , and one gene that was lost during the evolution of vertebrates
When they administered semaglutide to lab animals, the c-Fos distribution indicated that a number of brain regions were being indirectly activated by the GLP-1R agonist that had not shown up as being directly activated (Gabery et al., 2020)
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The majority of these cells in the choroid plexus are NK/ILC1s and ILC2s, with only a few ILC3s being detected within the CNS [137]
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