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In tissues with higher natural HGF expression (like the hippocampus), the amplification effect is expected to be more pronounced than in tissues with low HGF

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Source: Walker RF, Bercu BB JAAM 1:219-225, 1998 As seen in Figure 9, the response to GHRP in adolescent and adult subjects was comparable even though endogenous GHRH declines with advancing age

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