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In DKD, almost all pathogenesis is inseparable from the overactivation of ROS, which is the connection point between metabolism abnormalities and hemodynamic changes[89]

(106), the mTOR pathway increases GPX4 protein synthesis and sterol response element binding protein (SREBP)-mediated lipogenesis to encourage resistance to ferroptosis (107)

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BMC Genomics 15:549

Since polygenic risk score calculation requires large GWAS datasets, some neurodegenerative disorders such as frontotemporal dementia (FTD) or ALS currently lack well-established standards like those available for AD or PD (Lambert et al., 2023)