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[PubMed: 1586274] 254

E296 - Malic acid Malic acid: Malic acid is an organic compound with the molecular formula C4H6O5

Some gut bacterial metabolites can interfere with A aggregation [138]

In the DSM-IV, the disorder was classified within the broader category of pervasive developmental disorders, with specific diagnostic criteria involving social, communicative, and behavioral impairments

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A comprehensive review of recent clinical data highlights that while folate deficiency is common among individuals with ASD, maternal folic acid supplementation does not correlate with higher risk of the disorder, indeed folate therapy has been associated with improved neurodevelopmental outcomes (Vasconcelos et al., 2025)