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Short- and long-term changes in health-related quality of life with weight loss: results from a randomized controlled trial

One notable example is AZD3965, an inhibitor of MCT1/2, which has undergone a phase I clinical trial (NCT01791595) in patients with advanced cancer

Nonalcoholic fatty liver disease: multimodal treatment options for a pathogenetically multiple-hit disease

Annals of Internal Medicine, 177(8), 10161027

Among them, flavonoids are particularly outstanding in the treatment of liver disease

By contrast, small molecules like orforglipron are manufactured through convergent organic synthesis, a mature technology that the pharmaceutical industry has optimized over more than a century