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In the REDEFINE 1 phase III trial, participants lost over 20% of body weight on average over 68 weeks using the CagriSema combination (cagrilintide plus semaglutide)

They reduce homocysteine levels, which, when elevated, can increase the risk of osteoporosis

However, the efficacy was insufficient for drug registration

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People who are not used to high-intensity exercise or who have certain medical conditions may need to take it slowly or seek the help of a professional trainer when beginning a HIIT exercise routine

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