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The harsh environment of the stomach often breaks down the glutathione molecule before it can ever be absorbed

Glutathione S-transferase polymorphisms and risk of ovarian cancer: a HuGE review

GSSG is then recycled back to GSH by GSH-reductase using NADPH as cofactor and the ratio of GSH to GSSG regulates redox dependent cell signaling

A) Alignment of substrate binding loop in GS enzymes from plant, animal and fungal kingdom compared to homoGlutathione synthetase of Glycine max (hGS)

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