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This transgenic mouse overexpresses the human amyloid precursor protein (APP) carrying two familial AD mutations: The Swedish mutation (KM670/671NL), which increases total A production by enhancing -secretase cleavage, and the Indiana mutation (V717F), which alters -secretase cleavage to favor production of the more aggregation-prone amyloid-beta 142 peptide (A 142 ) [464467]

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Glucagon-like peptide-1 (GLP-1) receptor agonists are injectable medications licensed for type 2 diabetes and, in some formulations, weight management

10.1093/emboj/20.17.4639 91 Vicente-ManzanaresM.Snchez-MadridF

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