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Intranasal administration of DSIP analogs reduces brain infarction volume in stroke models, suggesting potential applications for cerebrovascular injury prevention
Campbell BC, Meretoja A, Donnan GA, Davis SM
Citrulline is converted to arginine in the kidneys, resulting in higher and more sustained plasma arginine levels compared to direct arginine supplementation
Theres no evidence for this in humans
An ATP-depleting futile 5-oxoproline cycle related to the glutathione synthetic pathway was recently proposed to explain many of the biochemical features of nephropathic cystinosis (38,39)
Unlike orally delivered chelators, which must survive harsh GI conditions and extensive hepatic first-pass effect before reaching systemic circulation, IN drugs only need to cross the nasal epithelium or can directly access the brain through neuronal pathways
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