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In further experiments, systemic injections of relatively high doses (125 g) of thymulin or of an analogue peptide (PAT) deprived of hyperalgesic effect, have been shown to reduce the inflammatory pain and the upregulated levels of cytokines induced by endotoxin (ET) injection

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However, betaine treatment may have some disadvantages because of an increase in methionine that is not found with folic acid treatment

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