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Some people find they feel better with a higher initial dose, while others prefer to start slow

Conversely, if you carry variants associated with higher baseline weight set-point (FTO rs9939609), you might benefit from more aggressive GLP-1 dosing paired with optimized testosterone levels to preserve muscle during a deeper calorie deficit

The researchers note limitations, including that this study was small in size (66 participants), so its not a strong source of evidence at this time

LUPKIN: That is correct

By contrast, participants receiving placebo lost an average of only 2.6% of their body weight

Z Gastroenterol 1992