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The mechanism of GLP-1s anti-inflammatory action is still being studied, however its action has been demonstrated to involve regulating lymphocyte proliferation, maintaining regulatory peripheral T cells

Metformin seems to be effective for reducing gestational weight gain, neonatal hypoglycaemia and macrosomia, but its efficacy for glycaemic control in GDM has not been demonstrated

But what is it that influences the choices

Cost and insurance coverage newer drugs can be harder to access

The bottleneck logic that makes it self-contained: Inflammation bottleneck KPV

Older adults and people taking metformin or acid-suppressing drugs who have confirmed low levels or absorption issues (NIH ODS)