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Since letrozole can inhibit estrogen levels in the process of COS, theatrically letrozole may help patients with borderline ovarian tumors in reducing the risk of tumor recurrence ( Safety Initially, there was concern that letrozole for OI may be associated with teratogenic effects on the infants ( Letrozole may well be teratogenically safer because its half-life virtually assures elimination from the body before implantation

other effects such as vomiting, diarrhea, constipation, and abdominal discomfort may also occur