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Ther Adv Gastroenterol 2:157163 Loomba R, Lutchman G, Kleiner DE et al (2009) Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis

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The echocardiography substudy of the STEP-HFpEF indicated that semaglutide ameliorated adverse cardiac remodeling among patients with obesity-related HFpEF [90]

It could be hypothesized that more advanced disease may be more resistant (or very high-risk groups more non-responsive) to the beneficial effects of GLP-1 receptor agonists on CV outcomes