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The delayed-release formula is intended to reach the lower intestines without succumbing to the harsh environment of the upper digestive system.* Historically, peptides have been notoriously difficult to absorb orally

10.3389/fphys.2021.669356 Front Physiol

Intramuscular (IM) administration of B12 allows for direct delivery, bypassing the digestive system and ensuring efficient absorption, particularly in individuals with malabsorption or gastrointestinal issues

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We encourage anyone with relevant safety data to contribute to that record

Some people report positive results with other treatments, but those with true pernicious anemia are unlikely to benefit at all