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Simultaneous administration may be suitable for patients requiring immediate intervention for both conditions

ASS1 downregulation has been reported to be associated with advanced tumor stage, high local recurrence rate, and poor relapse- and metastasis-free survival (Nicholson et al., 2009

Most gastrointestinal symptoms, like nausea, typically subside within about eight days

Other possible side effects are sudden weight gain, blurred vision or allergic reactions

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Intranasal treatment of salvinorin A, a highly selective non-opioid kappa opioid receptor agonist, reduced neuroinflammation and BBB permeability in transient MCAO mice (Misilimu et al., 2022)