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After a 4-hour fast, mice were intraperitoneally injected with 2 g/kg body weight arginine in sterile 0.9% saline

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Specific FDA concerns: Increased heart rate, systemic vasodilatory reactions, limited clinical safety data, immunogenicity risk

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Targeted modifications could: delete negative regulators of biofilm formation (e.g., c-di-GMP phosphodiesterases) to lock strains into a high-adhesion phenotypic state