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Luk Tenora et al

The sustained weight loss in Amgen's study appears to contrast with results seen in clinical trials on Zepbound and Wegovy

Chen Y, Mi Y, Zhang X, Ma Q, Song Y, Zhang L, et al

The mechanism involves activation of the PI3K/Akt/GSK-3 signaling pathway, which reduces Drp1 phosphorylation at Ser616 while enhancing its phosphorylation at Ser637, thereby inhibiting Drp1-mediated mitochondrial fission