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In addition, a post-marketing study also revealed that their use increases all-cause mortality in patients 50 years and older with RA who have at least one CV risk factor

The second limiting amino acid, representing the next most deficient amino acid, can also negatively impact growth even when the first limiting amino acid is supplemented (58)

DPP-4 inhibitors are not associated with increased CV risk

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10.1371/journal.pone.0031211 46 El-AnsaryA.BjrklundG.KhemakhemA