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Olaparib diluted in 200l of 6.8(DMSO):60(PEG300):132(H2O) was administered daily by oral gavage for the following 3 weeks

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The regulation of the VHLHIF pathway is also related to iron metabolism and ferroptosis in ccRCC, as iron levels are significantly higher in RCC cells and the tumor microenvironment than in normal renal tissue (77), and as HIF-1 mediates the cellular upregulation of TfRC and heme oxygenase (HO) expression, promoting cellular iron accumulation (78, 79)