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Insulin resistance and endothelial dysfunction constitute a common therapeutic target in cardiometabolic disorders

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In one study, three healthy male subjects receiving daily subcutaneous MT-II dosed at 0.01 mg/kg variously reported the following side effects during the two-week course of administration [1]: Moderate to severe nausea Repetitive yawning and stretching Spontaneous erections Fatigue Drowsiness Additional studies have linked MT-II administration with the darkening of pre-existing naevi (moles) and the development of new ones

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10.1093/gerona/glu314 99 MarchandF.MoreauC.KuchcinskiG.HuinV.DefebvreL.DevosD

In this context, early intervention with glutamate receptor blockade after noise exposure has been hypothesized to prevent excitotoxic injury to afferent synapses of inner hair cells