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Confirmation of the diagnosis requires a histological analysis of the prostatic tissue through a medical operation employed to obtain tissue samples from the prostate gland for analysis, known as transrectal biopsy

doi: 10.3389/fphar.2018.00453 Received 28 February 2018 Accepted 18 April 2018 Published 15 May 2018 Volume 9 - 2018 Edited by Nabil Eid, Osaka Medical College, Japan Reviewed by Hartmut Jaeschke, University of Kansas Medical Center, United States

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Depending on the skin color, medium brown skin requires one to three months, and dark skin requires more than two years of treatment

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doi:10.5114/ceji.2015.50825