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where E m represents the maximal stimulation of the system, K A is the agonist-receptor dissociation constant, in molar concentration, [ A ] is the molar concentration of ligand and is the operational measure of efficacy in the system, which incorporates signalling efficacy and receptor density

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The correlation coefficients of acyl-carnitines were similar in subjects at baseline, after follow-up, and in healthy controls (Figure 3)

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