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Gen Comp Endoc 148:273281 Kellner R, Mermet J-M, Otto M, Valcarcel M, Widmer HM (2004) Analytical chemistry

Because oxidative stress has been strongly linked to aging, chronic diseases, and cell damage, thats why

Glycogen Synthase Kinase 3-dependent phosphorylation decreases gephyrin cluster size, whereas phosphorylation by ERK decreases size and density of postsynaptic gephyrin clusters and is critical for the Ca2+-dependent cysteine protease (calpain-1) degradation of gephyrin

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