5 These benefits might come from several factors: Weight loss itself improves mood and self-esteem Reduced inflammation (which is linked to depression) Direct effects on GLP-1 receptors in the brain, which are present in areas involved in mood regulation Improved physical function and mobility Healthier eating habits developed while on the medication Evidence suggesting caution is needed However, pharmacovigilance studies (which analyse reports of side effects submitted to drug safety databases) have identified signals for psychiatric adverse events with GLP-1 medications, including semaglutide
Collectively, these findings raise the possibility that the mechanism of glucocorticoids increasing serum IGF-I levels is by directly inducing post-IGF-IR signaling resistance
And even just with that, I wont get perfect compliance: 20% wont remember to take the pill
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Journal of the American Chemical Society 127 , 52615270, (2005)