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While this peptide is a potent agonist for cAMP production, it is a biased agonist, with a preference for G protein-mediated signalling relative to -arrestin recruitment when compared to GLP-1 and exendin-4 26

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Furthermore, the individual metabolic pathways identified by our in silico model displayed significant overlap with the findings from our in vitro enteroid model and our method using untargeted metabolomics, demonstrating the potential value of this metabolic modeling approach