What level of plasma homocyst(e)ine should be treated
Those enzymes with high metabolic capacity have Michaelis constants very much higher than any substrate concentrations likely to be found clinically
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Administration of CBP or LDH inhibitors, or cell-penetrating peptides that can specifically block the lactylation of MRE11, can reduce the lactylation of MRE11, inhibit HR, and enhance the sensitivity of tumor cells to chemotherapeutic agents such as cisplatin, PARPi, etc [26]
doi: 10.1016/j.ymthe.2022.09.002 32 ZhangJRuizMBerghPOHenricssonMStojanoviNDevkotaRet al