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Two DNA methylation transferases (DNMTs) catalyze cytosine methylation ( de novo methylation, and DNMT1, which maintains methylation by methylating newly synthesized DNA strands (Vogelstein et al., 2013)

For decades, treatment of urea cycle disorders has consisted of nitrogen scavengers, dietary protein restriction, arginine or citrulline supplementation, calorie support, and liver transplant

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Indeed, although our screen indicates a decrease in total cell count upon treatment, suggesting a cytotoxic effect, there was limited change to variant distribution, suggesting that there was a global decrease in the population rather than a specific sub-population of sensitive mutants

Why is nutritional data and experimental data so contradictory