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During food consumption, there is a decrease in the activity of LS GLP-1R neurons (Figure 4), and chemogenetic or optogenetic activation mimics liraglutides anorectic effects (Figure 5)

This reduces overall food intake and prevents overeating

The key insight is that for individuals using fentanyl or those with severe OUD, induction is a critical juncture where many patients are lost

That timeframe refers to pharmacologic clearance, while noticeable effects such as appetite suppression and blood sugar control typically fade earlier as blood levels decline

Consult your healthcare provider before use if you are pregnant, nursing, taking medications, or have a medical condition

Alexis Cutchins: Yes, absolutely