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As these secondary events may be unpredictable and the mortality rate for MALA approaches 50%, Metformin has been contraindicated in moderate and severe renal impairment

In Study B, participants receiving bremelanotide twice daily exhibited significantly greater reduction in body weight compared to placebo (-1.7 kg vs -0.9 kg, respectively) and a reduction in total caloric intake of between 398469 kcal compared to placebo over four days