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Glutathione (GSH), a major thiol antioxidant is a multifunctional intracellular antioxidant It is one of the most important cellular antioxidants due to its high concentration and its role in maintaining the redox state of the cell

The clinician should also determine the onset and duration of the lesion, the presence of systemic signs and symptoms, drug use and smoking habits as well as the number, distribution, size, shape and colour of the pigmentation

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