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GLP-1 exerts its action through the GLP-1 receptor (GLP-1R) 4 expressed in the pancreas, other peripheral tissues, and the central nervous system

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The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells