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Who GLP-1 Therapy Applies To and When Cost-Per-Outcome Matters Most GLP-1 injectables are indicated for type 2 diabetes (semaglutide, tirzepatide) and chronic weight management in individuals with obesity or overweight plus comorbidities (all formulations)
Abstract Sodium-glucose cotransporters inhibitors (SGLT2-i) and GLP-1 receptor agonists (GLP1-RA) are glucose-lowering drugs that are proved to reduce the cardiovascular (CV) risk in type 2 diabetes mellitus (T2DM)
Down 15lbs
This review summarizes that the effect of GLP-1 is not just through its peripheric effects, but also through its central effects on reward processing as assessed by injection of GLP-1 analogs or GLP-1 itself to intra-NTS, NAc, VTA, LH, lPBN, SUM, BNST, LS for palatable food intake, intra-VTA, NAc, and LS for cocaine, intra-NAc for amphetamine, intra-NAc, NTS, dLS for alcohol, and intra-NTS and IPN for cocaine