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Finally, many exhibit anti-fibrotic and cardiomyocyte-protective actions: they interfere with fibrosis-related pathways (TGF-/Smad, etc.), inhibit cardiac fibroblast activation, and reduce pathological deposition of extracellular matrix in the heart (Xiao et al., 2018

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Exacerbating the problem, most patients get little to no help with the required lifestyle changes

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doi:10.1001/jamanetworkopen.2023.16776 13Joint Task Force on Practice Parameters