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These effects are typically temporary and tend to subside without intervention

Antidepressants are more effective when taken with additional vitamin B12

Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits

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This may be because the Peptide may be a foreign synthetic substance that needs extra effort from the stomach to digest

Smaller studies by Georgiades et al