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High-Frequency Spinal Cord Stimulation Recenty published randomized crossover SENZA-PDN study with 216 participants proved that high-frequency 10-kHz spinal cord stimulation (SCS) significantly decreased pain severity and provided additional clinically meaningful improvements in a quality of life questionnaire and overall functioning for patients with peripheral DPN

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In support of this observation, over expression of GS in a yeast model failed to increase GSH levels, whereas overexpression of GCL did [18]

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