The FDA has approved multiple GLP-1 agents for chronic weight management in adults with obesity or overweight status with weight-related comorbidities
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Wegovy and Zepbound carry the weight-management indications
Schimelpfening, Nancy
When these brain receptors were pharmacologically inhibited or genetically removed in mice, the drugs' ability to reduce inflammation was lost
SREBP2 is a major participant in the cholesterol biosynthesis pathway, functioning as a key transcriptional regulator of cholesterol synthesis (21, 22)