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No acute or chronic effects on systolic blood pressure were observed in DIO mice receiving twice-daily oral PL7737 at 20 mg/kg for two weeks, suggesting the compound lacks the cardiac effects observed in other melanocortin compounds (136)

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In the SUSTAIN 7 study, semaglutide demonstrated greater effectiveness than other GLP-1 receptor agonists, showing marked reductions in both HbA1c and body weight compared to dulaglutide [8]