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Long-term studies in animal models have examined whether chronic IGF1 LR3 use affects tumor growth or progression, an important consideration given the role of IGF-1 signaling in cancer biology

A study found that long-term IGF-1 administration in aged animals increases neurogenesis, vascular density and utilization of glucose in parts of the brain involved in memory and learning [8]

Similar to its effects on GLUT4 translocation, insulin stimulates the translocation, to the plasma membrane, of several fatty acid transporters, including CD36/FAT, FATP1, FATP4, and FATPm

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This shapes whether the signal is short and pulse-like or steadier and ongoing

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