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38 The p120 conditional knockout (KO) mice die young (within 21 days of their birth) and demonstrate progressive mucosal erosion and terminal bleeding, similar to what is observed in the dominant-negative cadherin mouse model of colitis and associated cancer, as described above

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The high quantity of equine intestinal -defensins and the biological activity of enteric DEFA1 against microorganisms emphasizes the importance of equine intestinal defensins in the protection of the horse against infections of the intestinal tract and the regulation of the intestinal microbiome, respectively