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Individuals with certain medical conditions or health concerns, such as kidney disease, liver disease, certain blood disorders, or allergies to specific vitamins, may need to avoid or modify the therapy

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Blain in 2008 performed a randomised controlled trial

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Some plant-based foods, such as fortified breakfast cereals, plant-based milk alternatives (e.g., soy milk, almond milk), and nutritional yeast, are fortified with Vitamin B12 (11)

There are insufficient high-quality randomised controlled trials to support their use for weight loss