Their effects, while promising, are primarily observed in preclinical settings, and their clinical relevance in preserving ovarian function remains to be validated (Chen et al., 2022)
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Effect of sodium-glucose transporter 2 inhibitors on sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
However, the TFA acid added to the biological sample probably reduced GSSG to a reduced form of glutathione because the intensity of the GSSG ions was very low for the sample with the addition of TFA (Fig
Some contain degradation products
Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload