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The appropriate concentrations of DHLA and LA to set distinct redox potentials were calculated from the Nernst equation based on the standard reduction potential of lipoic acid ( E LA ) of 290 mV at pH 7.0 (Lees and Whitesides, The redox potential for each of the two redox pairs is defined by the Nernst equation using the respective midpoint potential and ratios ( Q ) of oxidized to reduced roGFP and LA to DHLA, respectively (Equation 2)

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10.1016/j.jpba.2017.05.010 46 RizzutiA.AlvarengaC.StockerG.FragaL.SantosH

More serious but rare safety considerations include pancreatitis (discontinue if suspected), gallbladder disease, potential thyroid C-cell tumors (based on rodent studies), risk of hypoglycemia when used with insulin or sulfonylureas, and potential for acute kidney injury with severe dehydration

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