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Besides, vitamin B12, methylcobalamin has neurological effect indirectly, methylation of myelin shelth phospholipids via 5-methyltetrahydroxyfolate-homocystine methyltransferase (MTR) reaction
The drug can cross the blood-brain barrier (BBB) and activate GLP-1R in the CNS [49, 50], thus producing neuroprotective and anti-inflammatory effects [50,51,52,53,54,55]
At steady state, the amount of drug being administered each week equals the amount being eliminated, creating a stable concentration
Its an option, but generally the subcutaneous injection is more efficient and predictable in effect (nearly 100% bioavailability via injection versus variable absorption nasally or orally)
Cagrilintide is still investigational and only available in supervised clinical research settings
Strachan, D
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