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Other neurochemicals, including serotonin, neurokinin B, and calcitonin gene-related peptide (CGRP), are believed to influence the sensitivity of the thermoregulatory center and may contribute to both the frequency and severity of hot flashes

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in particular, it reduces hepatic glucose production through suppression of gluconeogenesis and increased oxidation of fatty acids, inhibits lipolysis and subsequent FFA release from the adipose tissue, enhances glucose uptake and storage from the muscle, and reduces intestinal glucose absorption [32]

1998, by Raun et al

Skip the missed dose and resume your normal schedule the next daynever double up or adjust timing without guidance