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Preclinical studies in rodents with long-acting GIP, GLP-1, and GLP-2 analogues, alongside related clinical trials, suggest these molecules are safe, and furthermore, may improve overall bone health

Nangaku M, Takama H, Ichikawa T et al (2023) Randomized, double-blind, placebo-controlled phase 3 study of bardoxolone methyl in patients with diabetic kidney disease: design and baseline characteristics of the AYAME study

They can also be used in combination with lifestyle changes for weight loss, although most people regain most or all of the lost weight after stopping medication use

HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, et al

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It may also have anti-aging effects and may help to reduce the risk of certain diseases, such as diabetes and cancer